11/30/2023 0 Comments Harvard origami fish grabberTo be activated most effectively, DCs likely need to experience tumor antigens and immune-boosting CpG adjuvant molecules at particular ratios (stoichiometries) and configurations that register with the density and distribution of receptor molecules on their cell surface. These approaches use implantable or injectable biomaterial-based scaffolds that present tumor-specific antigens, and biomolecules that attract dendritic immune cells (DCs) into the scaffold, and activate them so that after their release they can orchestrate anti-tumor T cell responses against tumors carrying the same antigens. The Wyss Institute has developed cancer vaccines to improve immunotherapies. DNA nanotechnological devices for therapeutic drug deliveryĭNA nanostructures have future potential to be widely used to transport and present a variety of biologically active molecules such as drugs and immune-enhancing antigens and adjuvants to target cells and tissues in the human body.ĭNA origami as high-precision delivery components of cancer vaccines Wyss Institute researchers are providing a suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. DNA nanostructures with their potential for cell and tissue permeability, biocompatibility, and high programmability at the nanoscale level are promising candidates as new types of drug delivery vehicles, highly specific diagnostic devices, and tools to decipher how biomolecules dynamically change their shapes, and interact with each other and with candidate drugs.
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